Month: November 2018

Computing Machinery and Intelligence by Alan Turing

This classic paper from 1950 was written by Alan Turing. This is where he first introduced the question “Can Machine Think?” and to answer that question he proposed “The Imitation Game”. The paper not only presents the computational or mathematical aspect of learning machine but also discusses theology, philosophy to telepathy and how can we start making this type of machine.

[slideshare id=122663772&doc=20181107tahsinaituring-181110155731]

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Modeling Human Disease with iPSC

Induced Pluripotent Stem Cell (iPSC) has opened up new approaches in disease modeling, personalized medicine, cell therapy, regenerative medicine and so o. Here is my presentation slide on Human Disease modeling with iPS cell.

[slideshare id=120899379&doc=modelinghumandiseasewithipsc-extended-181027014907]

Helpful references:

  1. Ardhanareeswaran, K., Mariani, J., Coppola, G., Abyzov, A. & Vaccarino, F. M. Human induced pluripotent stem cells for modelling neurodevelopmental disorders. Nat. Rev. Neurol. 13, 265–278 (2017).
  2. Chen, Y.-W. et al. A three-dimensional model of human lung development and disease from pluripotent stem cells. Nat. Cell Biol. 19, 542–549 (2017).
  3. Dutta, D., Heo, I. & Clevers, H. Disease Modeling in Stem Cell-Derived 3D Organoid Systems. Trends Mol. Med. 23, 393–410 (2017).
  4. Ebert, A. D., Liang, P. & Wu, J. C. Induced pluripotent stem cells as a disease modeling and drug screening platform. J. Cardiovasc. Pharmacol. 60, 408–16 (2012).
  5. Kondo, T. et al. Modeling Alzheimer’s disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cell Stem Cell 12, 487–96 (2013).
  6. Li, L., Chao, J. & Shi, Y. Modeling neurological diseases using iPSC-derived neural cells. Cell Tissue Res. 371, 143–151 (2018).
  7. Liu, C., Oikonomopoulos, A., Sayed, N. & Wu, J. C. Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond. Development 145, dev156166 (2018).
  8. Shaheen, N., Shiti, A. & Gepstein, L. Pluripotent Stem Cell-Based Platforms in Cardiac Disease Modeling and Drug Testing. Clin. Pharmacol. Ther. 102, 203–208 (2017).
  9. Shi, Y., Inoue, H., Wu, J. C. & Yamanaka, S. Induced pluripotent stem cell technology: a decade of progress. Nat. Rev. Drug Discov. 16, 115–130 (2017).
  10. Siller, R., Greenhough, S., Park, I.-H. & Sullivan, G. J. Modelling human disease with pluripotent stem cells. Curr. Gene Ther. 13, 99–110 (2013).
  11. Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861–72 (2007).
  12. Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663–76 (2006).
  13. Workman, M. J. et al. Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nat. Med. 23, 49–59 (2017).
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